疯狂飞艇

师资队伍

teaching staff

正高

鲍锦库

发布时间 : 2016年06月10日 浏览量 : 1832

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博士 教授 博导

职务:

zhongguoshengwuhuaxueyufenzishengwuxuehuitangfuhewuzhuanyeweiyuanhuiweiyuan、changwuweiyuan

疯狂飞艇zhongguoshengwuhuaxueyufenzishengwuxuehuishengwuhuaxueyufenzishengwuxuejiaoxuezhuanyeweiyuanhuiweiyuan、changwuweiyuan

zhongguoshengwuhuaxueyufenzishengwuxuehuinongyeshengwuhuaxuefenweihuilishi

zhongguoshengwugongchengxuehuitanggongchengzhuanyeweiyuanhuiweiyuan

guojiningjisuweiyuanhuiweiyuan

联系方式:

办公电话:

电子邮件: .cn

学位简历:

疯狂飞艇1987.09-1991.07: zhejiangdaxueshengwuxishengwuhuaxueyuweishengwuxuezhuanye,benke

1991.09 –1994.07: sichuandashengwuxishengwuhuaxuezhuanye,lixueshuoshi

2000.09 –2003.12: sichuandaxueshengmingkexuexueyuan,lixueboshi

工作简历:

疯狂飞艇1994.07–1996.07: sichuandaxueshengmingkexuexueyuan,zhujiao

1994.09 –1995.09:

zaizhongguonongkeyuanzhibaosuozhiwubingchonghaishengwuxueguojiazhongdianshiyanshihezhongguonongkeyuanchumuyanjiusuokezuoyanjiu

疯狂飞艇1996.07–1998.07:

sichuandaxueshengmingkexuexueyuan,jiangshi

1998.07–2005.07:

sichuandaxueshengmingkexuexueyuanfujiaoshou

2005.07-2006.07:

sichuandaxueshengmingkexuexueyuanjiaoshouboshishengdaoshi

2006.07 –zhijin:

sichuandaxueshengmingkexuexueyuanjiaoshou,boshishengdaoshi

个人科研工作简介

1)研究方向及主要学术成果:

疯狂飞艇lizufengkuangfeitingguofengfudetianranyaoyongziyuanbaoku,weiraoaizibingdengchuanranxingjibing、linchuangchangjianexingzhongliudengjibingjixinyaochuangzhidengguojiazhanlvexuqiu,yijuyouteyitangjiehenenglidefeimianyilaiyuandeningjisuweizhuxian,jichengxiandaishengmingkexuejishufangfa,jinxingjuyouzizhuzhishichanquan、kangbingduhekangzhongliuhuoxingdeningjisudenghuoxingdafenzideshaixuan、guimozhibei、jiyinkelongyudanbaixulie、zhongzudanbaibiaoda、shengwuhuoxingjiqijiyuzhongliufashengfazhandiaokongwangluodefenzijizhi、jiyujiegoudefenzishejihegaizaoyijidanbaiduotaishujukudegoujianheliyongzhuanjiyinzhiwudalianghuoquhuoxingdanbaidengxitongyanjiu。fahuishengmingkexue、yixuehexinxikexuedengxueketedianjixuekejiaochayoushi,yinruxitongshengwuxuezhengtixing、xinxihuahewangluodiaokongdeyanjiucelvehelinian,jichengshengwuhuaxueyufenzishengwuxue、xibaoshengwuxue、fenziyaolixue、zuxuehexitongshengwuxuedengjishufangfa,xitongyanjiuzhongcaoyaodanbaiduotaikangzhongliufenzijizhijiqiqianzaibabiao,tuopile“ningjisutanzhen-zhongliuxibaochengxuxingsiwangxiangguandanbai-mirnaxianghudiaokongwangluo”yanjiuxinfangxiang,weijiyuzhongyaoyuanhuoxingdanbaiduotaiweixiandaohuohouxuanhuahewudegongnengjizhiyanjiutigongshifanxingdexinsilubingweiyuantouchuangxinyaowuyanfatigongtongyongmoshi。

2)科研项目:

国家自然科学基金项目:

疯狂飞艇1、guatanglian、anjisuancelianjituanyuhuangjingningjisushengwuxuehuoxingyanjiu(pizhunhao:39770178),1998 -2000,xiangmufuzeren

2、huangjingningjisujiegouyushengwuxuehuoxingguanxiyanjiu(pizhunhao: 30000032),2001-2003,xiangmufuzeren

3、dingdiantubianyanjiuhuangjingningjisuiijiegouyugongnengguanxi(pizhunhao: 30270331),2003-2005,xiangmufuzeren

4、zhongzuhetubiankangaizibingduhuangjingningjisuiijiqifuhewujingtijiegouyanjiu(pizhunhao:30670469),2007-2009,xiangmufuzeren

5、huangjingningjisuyoudaozhongliuxibaozishihediaowangdefenzijizhiyanjiu(pizhunhao:30970643),2010-2012,xiangmufuzeren

6、ningjisuyoudaozhongliuxibaochengxuxingsiwangdefenzijizhi(pizhunhao:81173093),2012-2015, xiangmufuzeren

疯狂飞艇7、gaoxiaodimianyiyuanxinghuangjingningjisudefenzisheji(pizhunhao: 81373311),2014-2017, xiangmufuzeren

8、shibajieguojiningjisuhuiyi18th international lectin meeting, july, 1999, u.k),yingguo

9、dishijiujieguojiningjisuhuiyi(19th international lectin meeting, march, 2001, brazil), baxi

疯狂飞艇10、diershijieguojiningjisuhuiyi(20th international lectin meeting, may,2002,denmark), danmai

11、diershiyijieguojiningjisuhuiyi(21th international lectin meeting, may, 2004, japan),riben

国家重大科技专项-转基因生物新品种培育:

“xinandiqukangshuidaoxiepoyinzijiyinkelongjigongnengyanzheng”(2009zx8009-072b)ziketifuzeren

国家高技术研究发展计划(863计划):

fanqieyingyangpinzhigailiangdejiyingongchengjishuyanjiu(2007aa10z122),2007-2010,ketifuzuzhang

省部级课题:

1、中国农科院植物病虫害生物学国家重点实验室开放课题: 葱莲凝集素的基因克隆,2002,项目负责人

疯狂飞艇2、sichuandaxuekejichuangxinjijin: chuantongzhongcaoyaozhongjukangbingduhuoxingdeganlutangjiehedanbaidejiyinkelongyubiaodayanjiu, 2004-2006,xiangmufuzeren

3、sichuanshengjiechuqingniankejijijin: zhuanzhiwuningjisujiyinpeiyangkangchongxinpinzhong(pizhunhao: 06zq026-035),2006-2008,xiangmufuzeren

4、sichuanshengkejigongguanxiangmu: chuantongzhongcaoyaozhongkangbingdukangzhongliudanbaidefenli、jiyinkelongbiaodajihuoxingyanjiu (pizhunhao: 2006z08-010),2006-2008,xiangmufuzeren

3)发表论文:

2016

Lei Wu, Tao Liu, Yan Xiao, Xing Li, Yanan Zhu, YanZhao, Jinku Bao*, Chuanfang Wu,Polygonatum odoratumlectin induces apoptosis and autophagy by regulation of microRNA-1290 and microRNA-15a -3p in human lung adenocarcinoma A549 cells,International Journal of Biological Macromolecules,2016, 85:217–226

Wei Zhang, Jianzong Li, Haiyang Wang, Hao Luo, Xin Wang, Nan Zhou, Chuanfang Wu, Jinku Bao*, Computer-aided identification of potential TYK2 inhibitors from drug database,Journal of Molecular Structure, 2016, 309-317

Jian-zong Li, Hao Luo, Xin Wana, Dan-feng Liang, Kai-min Lu, Jin-ku Bao*, Insilicoidentification of novel kinase inhibitors targeting HER2 from Natural Products for the treatment of HER2-positive breast cancer,,2016, In press

Tao Liu, Lei Wu, Di Wang, Haiyang Wang, Jinwu Chen, Chunlan Yang, Jinku Bao*, Chuanfang Wu, Role of reactive oxygen species mediated MAPK and NF-κB activation inPolygonatum cyrtonema lectin induced apoptosis and autophagy in human lung adenocarcinoma A549 cells,The Journal of Biochemistry, 2016, In press

Ya-nan Zhu, Li-kun Long, Yuan-yuan Li, Chuan-fang Wu, Jin-ku Bao*, Purification and Characterization of a Mannose-binding Lectin from theAllium macrostemonBunge with apoptosis-inducing activity,Phytomedicine,疯狂飞艇2016, In press

2015

Zhining Wan, Xin Li, Rong Sun, Yuanyuan Li, Xiaoyun Wang , Xinru Li, Li Rong a, Zheng Shi, Jinku Bao*, Computer-assisted identification of novel small molecule inhibitors targeting GLUT1,Journal of Molecular Structure, 2015, 1101: 57-65

Jing Li, Nan Zhou, Wen Liu, Jianzong Li, Yu Feng, Xiaoyun Wang, Chuanfang, Wu, Jinku Bao*, Discover natural compounds as potential phosphodiesterase-4B inhibitors via computational approaches,Journal of Biomolecular Structure and Dynamics, 2015, DOI: 10.1080/07391102.2015.1070749

Zi-jie Wang, Zhi-ning Wan, Xu-dong Chen, Chuan-fang Wu, Guo-long Gao,Rong Liu, Zheng Shi, Jin-ku Bao*, In silico identification of novel kinase inhibitors by targeting B-Raf from natural products database,J Mol Model疯狂飞艇, 2015, 21:102

Rong Sun, Xin Li, Yuanyuan Li, Xun Zhang, Xinru Li, Xiaoyu Li, Zheng Shi, Jinku Bao*, Screening of novel inhibitors targeting lactate dehydrogenase A via four molecular docking strategies and dynamics simulations,J Mol Model,2015,21: 133

Jianzong Li , Yu Feng , Xiaoyun Wang , Jing Li , Wen Liu , Li Rong and Jinku Bao*, An Overview of Predictors for Intrinsically Disordered Proteins over 2010–2014, Int. J. Mol. Sci疯狂飞艇. 2015, 16, 23446-23462

2014

Li C, Chen J, Lu B, Shi Z, Wang H, Zhang B, Zhao K, Qi W, Bao J*, Wang Y: Molecular switch role of Akt inPolygonatum odoratumlectin-induced apoptosis and autophagy in human non-small cell lung cancer A549 cells.PloS one2014, 9(7):e101526-e101526.

Li X, Sun R, Chen W, Lu B, Li X, Wang Z, Bao J*: A Systematic In Silico Mining of the Mechanistic Implications and Therapeutic Potentials of Estrogen Receptor (ER)-alpha in Breast Cancer.Plos One2014, 9(3).

Yu Y, Deng Y, Lu B-m, Liu Y-x, Li J, Bao J-k* : Green tea catechins: a fresh flavor to anticancer therapy.Apoptosis疯狂飞艇2014, 19(1):1-18.

Xu H-l, Wang Z-j, Liang X-m, Li X, Shi Z, Zhou N, Bao J-k*: In silico identification of novel kinase inhibitors targeting wild-type and T315I mutant ABL1 from FDA-approved drugs.Molecular Biosystems疯狂飞艇2014, 10(6):1524-1537.

Fu LL, Liu J, Chen Y, Wang FT, Wen X, Liu HQ, Wang MY, Ouyang L, Huang J, Bao JK* et al: In silico analysis and experimental validation of azelastine hydrochloride (N4) targeting sodium taurocholate co-transporting polypeptide (NTCP) in HBV therapy.Cell Proliferation2014, 47(4):326-335.

Wu L, Zhou N, Sun R, Chen XD, Feng SC, Zhang B, Bao JK*: Network-based identification of key proteins involved in apoptosis and cell cycle regulation.Cell Proliferation疯狂飞艇2014, 47(4):356-368.

Shi Z, An N, Lu BM, Zhou N, Yang SL, Zhang B, Li CY, Wang ZJ, Wang F, Wu CF, Bao JK*: Identification of novel kinase inhibitors by targeting a kinase-related apoptotic protein-protein interaction network in HeLa cells.Cell Proliferation疯狂飞艇2014, 47(3):219-230.

Wang H-L, Li C-Y, Zhang B, Liu Y-D, Lu B-M, Shi Z, An N, Zhao L-K, Zhang J-J, Bao J-K* : Mangiferin Facilitates Islet Regeneration and beta-Cell Proliferation through Upregulation of Cell Cycle and beta-Cell Regeneration Regulators.International Journal of Molecular Sciences2014, 15(5):9016-9035.

Shi Z, Chen J, Li C-y, An N, Wang Z-j, Yang S-l, Huang K-f, Bao J-k*: Antitumor effects ofconcanavalinA and Sophora flavescens lectin in vitro and in vivo.Acta Pharmacologica Sinica2014, 35(2):248-256.

Bangmin Lu , Bin Zhang, Wei Qi, Yanan Zhu, Yan Zhao, Nan Zhou, Rong Sun, Jinku Bao*, and Chuanfang Wu, Conformational study reveals amino acid residues essential for hemagglutinating and anti-proliferative activities ofClematis montanalectin,Acta Biochim Biophys Sin2014, 46: 923–934.

Zhou N, Zhang Y, Zhang J-C, Feng L, Bao J-K*: The receptor binding domain of MERS-CoV: The dawn of vaccine and treatment development.Journal of the Formosan Medical Association2014, 113(3):143-147.

Jing Li , Nan Zhou , Kun Luo , Wei Zhang , Xinru Li , Chuanfang Wu,Jinku Bao*:In Silico Discovery of Potential VEGFR-2 Inhibitors from Natural Derivatives for Anti-Angiogenesis Therapy,International Journal of Molecular Sciences2014, 15(9):15994-16011.

Xu G-B, Yang T, Bao J-K*, Fang D-M, Li G-Y: Isochaetomium A(2), a new bis(naphthodihydropyran-4-one) with antimicrobial and immunological activities from fungus Chaetomium microcephalum.Archives of Pharmacal Research疯狂飞艇2014, 37(5):575-579.

Xu G-B, Wang N-N, Bao J-K*, Yang T, Li G-Y: New Orsellinic Acid Esters from Fungus Chaetomium globosporum.Helvetica Chimica Acta2014, 97(1):151-159.

2013

Lu G, Hu Y, Wang Q, Qi J, Gao F, Li Y, Zhang Y, Zhang W, Yuan Y, Bao J* et al: Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26.Nature疯狂飞艇2013, 500(7461):227

Shi Z, Li C-y, Zhao S, Yu Y, An N, Liu Y-x, Wu C-f, Yue B-s, Bao J-k*: A systems biology analysis of autophagy in cancer therapy.Cancer Letters疯狂飞艇2013, 337(2):149-160.

Lin Y, Wang F, Yang L-j, Chun Z, Bao J-k*, Zhang G-l: Anti-inflammatory phenanthrene derivatives from stems of Dendrobium denneanum.Phytochemistry疯狂飞艇2013, 95:242-251.

Fu LL, Yang Y, Xu HL, Cheng Y, Wen X, Ouyang L, Bao JK*, Wei YQ, Liu B: Identification of novel caspase/autophagy-related gene switch to cell fate decisions in breast cancers.Cell Proliferation2013, 46(1):67-75.

Shi Z, An N, Zhao S, Li X, Bao JK*, Yue BS: In silico analysis of molecular mechanisms of legume lectin-induced apoptosis in cancer cells.Cell Proliferation疯狂飞艇2013, 46(1):86-96.

Li CY, Wang Y, Wang HL, Shi Z, An N, Liu YX, Liu Y, Zhang J, Bao JK*, Deng SP: Molecular mechanisms ofLycoris aureaagglutinin-induced apoptosis and G2/M cell cycle arrest in human lung adenocarcinoma A549 cells, both in vitro and in vivo.Cell Proliferation疯狂飞艇2013, 46(3):272-282.

Li X, Xu H-l, Liu Y-x, An N, Zhao S, Bao J-k*: Autophagy modulation as a target for anticancer drug discovery.Acta Pharmacologica Sinica疯狂飞艇2013, 34(5):612-624.

Wu L, Bao J-k*: Anti-tumor and anti-viral activities ofGalanthus nivalisagglutinin (GNA)- related lectins.Glycoconjugate Journal2013, 30(3):269-279.

Pu X, Qu X, Chen F, Bao J*, Zhang G, Luo Y: Camptothecin-producing endophytic fungus Trichoderma atroviride LY357: isolation, identification, and fermentation conditions optimization for camptothecin production.Applied Microbiology and Biotechnology2013, 97(21):9365-9375.

Shi Z, Wang Z-j, Xu H-l, Tian Y, Li X, Bao J-k*, Sun S-r, Yue B-s: Modeling, docking and dynamics simulations of a non-specific lipid transfer protein fromPeganum harmalaL.Computational Biology and Chemistry2013, 47:56-65.

Zhou N, Zhang J, Feng L, Lu B, Wang Z, Sun R, Wu C, Bao J*: IntApop: A web service for predicting apoptotic protein interactions in humans.Biosystems2013, 114(3):238-244.

Liu B, Bao J-K*, Yang J-M, Cheng Y: Targeting autophagic pathways for cancer drug discovery.Chinese Journal of Cancer2013, 32(3):113-120.

Gao F, Bao J*: Preliminary crystallographic analysis of neuraminidase N2 from a new influenza A virus.Acta Crystallographica Section F-Structural Biology and Crystallization Communications2013, 69:861-863.

Gao F, Bao J*: Crystallization and preliminary X-ray crystallographic analysis of the rhesus macaque MHC class I molecule Mamu-B*17 complexed with an immunodominant SIVmac239 Env epitope.Acta CrystallographicaSection F-Structural Biology and Crystallization Communications2013, 69:643-645.

Lv J, Wang Z, Zhang L, Wang H-L, Liu Y, Li C, Deng J, Yi W, Bao J-K*: Mangiferin Induces Apoptosis and Cell Cycle Arrest in MCF-7 Cells Both in vitro and in vivo.Journal of Animal and Veterinary Advances2013, 12(3):352-359.

2012

Li W-w, Li J, Bao J-k*: Microautophagy: lesser-known self-eating.Cellular and Molecular Life Sciences2012, 69(7):1125-1136.

Fu L-L, Wen X, Bao J-k*, Liu B: MicroRNA-modulated autophagic signaling networks in cancer.International Journal of Biochemistry & Cell Biology2012, 44(5):733-736.

Ouyang L, Shi Z, Zhao S, Wang FT, Zhou TT, Liu B, Bao JK*: Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis.Cell Proliferation2012, 45(6):487-498.

Fu LL, Zhao X, Xu HL, Wen X, Wang SY, Liu B, Bao JK*, Wei YQ: Identification of microRNA-regulated autophagic pathways in plant lectin-induced cancer cell death.Cell Proliferation2012, 45(5):477-485.

Wang Y, Liu Y, Wang H, Li C, Qi P, Bao J*:Agaricus bisporuslectins mediates islet beta-cell proliferation through regulation of cell cycle proteins.Experimental Biology and Medicine疯狂飞艇2012, 237(3):287-296.

Wang Y, Wang H, Liu Y, Li C, Qi P, Bao J*: Antihyperglycemic Effect of Ginsenoside Rh2 by Inducing Islet beta-cell Regeneration in Mice.Hormone and Metabolic Research2012, 44(1):33-40.

Xu H-l, Li C-y, He X-m, Niu K-q, Peng H, Li W-w, Zhou C-c, Bao J-k*: Molecular modeling, docking and dynamics simulations of GNA-related lectins for potential prevention of influenza virus (H1N1).Journal of Molecular Modeling2012, 18(1):27-37.

Wang N, Xu H-l, Zhao X, Wen X, Wang F-t, Wang S-y, Fu L-l, Liu B, Bao J-k*: Network-Based Identification of Novel Connections Among Apoptotic Signaling Pathways in Cancer.Applied Biochemistry and Biotechnology疯狂飞艇2012, 167(3):621-631.

2011

Liu JJ, Lin M, Yu JY, Liu B*, Bao JK*. Targeting apoptotic and autophagic pathways for cancer therapeutics.Cancer Letters.疯狂飞艇2011. 300(2):105-114.

Wang SY, Yu QJ, Bao JK*, Liu B.Polygonatum cyrtonemalectin, a potential antineoplastic drug targeting programmed cell death pathways.Biochemical and Biophysical Research Communications.2011. 406(4):497-500.

Li WW, Yu JY, Xu HL, Bao JK*.ConcanavalinA: a potential anti-neoplastic agent targeting apoptosis, autophagy and anti-angiogenesis for cancer therapeutics.Biochemical and Biophysical Research Communications疯狂飞艇. 2011. 414(2):282-286.

Li CY, Luo P, Liu JJ, Wang EQ, Li WW, Ding ZH, Mou L, Bao JK*. Recombinant expression ofPolygonatum cyrtonemalectin with anti-viral, apoptosis-inducing activities and preliminary crystallization.Process Biochemistry疯狂飞艇. 2011. 46(2): 533-542.

Li CY, Wang EQ, Cheng Y, Bao JK*. Oridonin: An active diterpenoid targeting cell cycle arrest, apoptotic and autophagic pathways for cancer theraputics.The International Journal of Biochemistry & Cell Biology. 2011. 43(5):701-704.

Fu LL, Zhou CC, Yao S, Yu JY, Liu B, Bao JK*. Plant lectins: targeting programmed cell death pathways as antitumor agents.The International Journal of Biochemistry & Cell Biology. 2011. 43(10):1442-1449.

Yang Y, Xu HL, Zhang ZT, Liu JJ, Li WW, Ming H, Bao JK*. Characterization, molecular cloning, and in silico analysis of a novel mannose-binding lectin fromPolygonatum odoratum(Mill.) with anti-HSV-II and apoptosis-inducing activities.Phytomedicine. 2011, 18(8-9):748-755.

He XM, Ji N, Xiang XC, Luo P, Bao JK*. Purification, characterization, and molecular cloning of a novel antifungal lectin from the roots ofOphioglossum pedunculosum.Applied Biochemistry and Biotechnology. 2011. 165(7-8):1458-1472.

Yu QJ, Li ZY, Yao S, Ming M, Wang SY, Liu B, Bao JK*. In silico analysis of molecular mechanisms ofGalanthus nivalisagglutinin-related lectin-induced cancer cell death from carbohydrate-binding motif evolution hypothesis.Applied Biochemistry and Biotechnology.2011. 165(3-4):1037-1046.

Zhang F, Li CY, Wang EQ, Li WW, Yu QJ, Wen X, Liu JJ, Bao JK*. The Global Component-Target Network in Panax Ginseng C.Letters in Drug Design & Discovery疯狂飞艇, 2011, 8, 181-188.

2010

Liu B, Wu JM, Li J, Liu JJ, Li WW, Li CY, Xu HL, Bao JK*.Polygonatum cyrtonemalectin induces murine fibrosarcoma L929 cell apoptosis and autophagy via blocking Ras-Raf and PI3K-Akt signaling pathways.Biochimie.疯狂飞艇2010. 92(12):1934-1938.

Liu B, Bian HJ, Bao JK*. Plant lectins: Potential antineoplastic drugs from bench to clinic.Cancer Letters. 2010. 287(1):1-12.

Yao Q, Wu CF, Luo P, Xiang XC, Liu JJ, Mou L, Bao JK*. A new chitin-binding lectin from rhizome ofSetcreasea purpureawith antifungal, antiviral and apoptosis-inducing activities.Process Biochemistry疯狂飞艇. 2010. 45(9): 1477-1485.

Zhang ZT, Peng H, Li CY, Liu JJ, Zhou TT, Yan YF, Li Y, Bao JK*.Polygonatum cyrtonemalectin induces murine fibrosarcoma L929 cell apoptosis via a caspase-dependent pathway as compared to Ophiopogon japonicus lectin.Phytomedicine疯狂飞艇. 2010. 18(1):25-31.

Li CY, Xu HL, Liu B, Bao JK*.ConcanavalinA, from an old protein to novel candidate antineoplastic drug.Current Molecular Pharmacology疯狂飞艇. 2010. 3(3):123-128.

Liu B, Cheng Y, Liu Q, Bao JK*, Yang JM. Autophagic pathways as new targets for cancer drug development.Acta Pharmacologica Sinica. 2010. 31(9):1154-64.

Ding J, Bao J*, Zhu D, Zhang Y, Wang DC. Crystal structures of a novel anti-HIV mannose-binding lectin fromPolygonatum cyrtonemaHua with unique ligand-binding property and super-structure.Journal of Structural Biology疯狂飞艇. 2010. 171(3):309-17.

2009

Liu B, Min MW, Bao JK*. Induction of apoptosis byConcanavalinA and its molecular mechanisms in cancer cells.Autophagy,2009. 5(3): 432-433.

Liu B, Cheng Y, Bian HJ, Bao JK*. Molecular mechanisms ofPolygonatum cyrtonemalectin-induced apoptosis and autophagy in cancer cells.Autophag疯狂飞艇y. 2009. 5(2):253-255.

Liu B, Cheng Y, Zhang B, Bian HJ, Bao JK*.Polygonatum cyrtonemalectin induces apoptosis and autophagy in human melanoma A375 cells through a mitochondria-mediated ROS-p38-p53 pathway.Cancer Letters.疯狂飞艇2009. 275(1):54-60.

Liu B, Li CY, Bian HJ, Min MW, Chen LF, Bao JK*. Antiproliferative activity and apoptosis-inducing mechanism ofConcanavalinA on human melanoma A375 cells.Archives of Biochemistry and Biophysics.2009. 482(1-2):1-6

Liu B, Zhang B, Min MW, Bian HJ, Chen LF, Liu Q, Bao JK*. Induction of apoptosis byPolygonatum odoratumlectin and its molecular mechanisms in murine fibrosarcoma L929 cells.Biochimica et Biophysica Acta(BBA) - General Subjects. 2009. 1790(8):840-844.

Peng H, Lv H, Wang Y, Liu YH, Li CY, Meng L, Chen F, Bao JK*.Clematis montanalectin, a novel mannose-binding lectin from traditional Chinese medicine with antiviral and apoptosis-inducing activities.Peptides.2009. 30(10):1805-1815.

Lv H, Kong Y, Yao Q, Zhang B, Leng FW, Bian HJ, Balzarini J, Van Damme E, Bao JK*. Nebrodeolysin, a novel hemolytic protein from mushroomPleurotus nebrodensis with apoptosis-inducing and anti-HIV-1 activities.Phytomedicine. 2009. 16(2-3):198-205.

Chen J, Liu B, Ji N, Zhou J, Bian HJ, Li CY, Chen F, Bao JK*. A novel sialic acid-specific lectin fromPhaseolus coccineusseeds with potent antineoplastic and antifungal activities.Phytomedicine疯狂飞艇. 2009. 16(4):352-360.

Liu B, Peng H, Yao Q, Li J, Van Damme E, Balzarini J, Bao JK*. Bioinformatics analyses of the mannose-binding lectins fromPolygonatum cyrtonema, Ophiopogon japonicusandLiparis noversawith antiproliferative and apoptosis-inducing activities.Phytomedicine. 2009. 16(6-7):601-608.

Ye SH, Chen S, Zhang F, Wang W, Tian Q, Liu JZ, Chen F, Bao JK*. Transgenic tobacco expressingZephyranthes grandifloraagglutinin confers enhanced resistance to aphids.Applied Biochemistry and Biotechnology. 2009. 158(3):615-30.

Li CY, Wang Y, Peng H, Bian HJ, Min MW, Chen LF, Liu Q, Bao JK*. In silico Analysis of the Potential Infection Mechanisms of Magnaporthe grisea from Horizontal Gene Transfer Hypothesis.Genomics, Proteomics & Bioinformatics. 2009. 7(3):77-86.

Li CY, Meng L, Liu B, Bao JK*.Galanthus nivalisagglutinin (GNA)-related lectins: Traditional proteins, Burgeoning drugs?Current Chemical Biology疯狂飞艇. 2009. 3:324-333.

Zhao Q, Wu CF, Wang WG, Yuan S, Bao JK*, Chen F. In vitro plantlet regeneration system from rhizomes and mannose-binding lectin analysis of Polygonatum cyrtonemaHua.Plant Cell, Tissue and Organ Culture.2009. 99(3): 269-275.

2008

Liu B, Xu XC, Cheng Y, Huang J, Liu YH, Liu Z, Min MW, Bian HJ, Chen J, Bao JK*. Apoptosis-inducing effect and structural basis ofPolygonatum cyrtonemalectin and chemical modification properties on its mannose-binding sites.BMB Reports. 2008. 41(5):369-375.

Liu C, Zhao X, Xu XC, Li LR, Liu YH, Zhong SD, Bao JK*. Hemagglutinating activity and conformation of a lactose-binding lectin from mushroom Agrocybe cylindracea.International Journal of Biological Macromolecules.2008. 42(2):138-144.

Liu Z, Liu B, Zhang ZT, Zhou TT, Bian HJ, Min MW, Liu YH, Chen J, Bao JK*. A mannose-binding lectin fromSophora flavescensinduces apoptosis in HeLa cells.Phytomedicine疯狂飞艇. 2008. 15(10):867-875.

Tian Q, Wang W, Miao C, Peng H, Liu B, Leng FW, Dai L, Chen F, Bao JK*. Purification, characterization and molecular cloning of a novel mannose-binding lectin from rhizomes ofOphiopogon japonicuswith antiviral and antifungal activities.Plant Science疯狂飞艇. 2008. 175(6): 877-884.

Xu XC, Zhong SD, Kai F, Li LR, Liu C, Liu B, Bao JK*. Preparation and characterization of a novel recombinant human parathyroid hormone (1-34) analog (Gly1-Gln26-rhPTH(1-34)) with enhanced biological activity. Protein & Peptide Letters. 2008. 15(8):854-860.

Ding JJ, Bao JK, Zhu DY, Zhang Y, Wang DC. Crystallization and Preliminary X-Ray Diffraction Analysis of a Novel Mannose-Binding Lectin with Antiretroviral Properties fromPolygonatum cyrtonemaHua.Protein and Peptide Letters.疯狂飞艇2008. 15(4):411-414.

2007

Luo YT, Xu XC, Liu JW, Li J, Sun YS, Liu Z, Liu JZ, Van Damme E, Balzarini J, Bao JK*. A novel mannose-binding tuber lectin fromTyphonium divaricatum(L.) Decne (family Araceae) with antiviral activity against HSV-II and anti-proliferative effect on human cancer cell lines.Journal of Biochemistry and Molecular Biology. 2007. 40(3):358-367.

Liu JW, Xu XC, Liu JZ, Balzarini J, Luo YT, Kong Y, Li J, Chen F, Van Damme E, Bao JK*. A novel tetrameric lectin fromLycoris aureawith four mannose-binding sites permonomer.Acta Biochimica Polonica.2007. 54(1):159-166.

Xu XC, Wu CF, Liu C, Luo YT, Li J, Zhao XP, Damme EV, Bao JK*. Purification and Characterization of a Mannose-Binding Lectin from the Rhizomes ofAspidistra elatiorBlume with Antiproliferative Activity.Acta Biochimica et Biophysica Sinica(Shanghai). 2007. 39(7): 507-519

学术专著

1. jin-ku bao. autophagy pathways and drug targets in cancer. in: autophagy: principles, regulation and roles in disease. 2011. nova science publisher. hauppauge ny, usa。

疯狂飞艇2.baojinku,《zishi: shengwuxueyujibing》diershibazhang: zhenduizishideyaowukaifahezhiliaodezhanwang。kexuechubanshe(2015,dierban)。

其它论著

An J, Liu JZ, Wu CF, Li J, Dai L, Van Damme E, Balzarini J, De Clercq E, Chen F, Bao JK*. Anti-HIV I/II activity and molecular cloning of a novel mannose/sialic acid-binding lectin from rhizome ofPolygonatum cyrtonemaHua.Acta Biochimica et Biophysica Sinica(Shanghai). 2006. 38(2):70-8.

Wu CF, Li J, An J, Chang LQ, Chen F, Bao JK*. Purification, Biological Activities, and Molecular Cloning of a Novel Mannose-Binding Lectin from Bulbs ofZephyranthes candidaHerb (Amaryllidaceae).Journal of Integrative Plant Biology. 2006. 48(2):223-231.

Gao S, An J, Wu CF, Gu Y, Chen F, Yu Y, Wu QQ, Bao JK*. Effect of amino acid residue and oligosaccharide chain chemical modifications on spectral and hemagglutinating activity ofMillettia dielsianaHarms. ex Diels. Lectin.Acta Biochimica et Biophysica Sinica疯狂飞艇(Shanghai). 2005. 37(1): 47-54.

Gong M, An J, LüHZ, Wu CF, Li YJ, Cheng JQ, Bao JK*. Effects of denaturation and amino acid modification on fluorescence spectrum and hemagglutinating activity ofHericium erinaceumLectin.Acta Biochimica et Biophysica Sinica(Shanghai). 2004. 36(5):343-350

Wu CF, An J, He XJ, Deng J, Hong ZX, Liu Chao, Lu HZ, Li YJ, Wang CJ, Chen F, Bao JK*. Molecular Cloning of a Novel Mannose-binding Lectin Gene from Bulbs ofAmaryllis vittata(Amaryllidaceae).Acta Botanica Sinica. 2004. 46(11):1301-1306.

Jiang FB, Du J, Yu XQ, Bao JK, Zeng XC. Metallomicellar catalysis: accelerated hydrolysis of BNPP by copper(II), zinc(II), and nickel(II) complexes of long alkanol-imidazole in CTAB micellar solution.Journal of Colloid and Interface Science疯狂飞艇. 2004. 273(2):497-504.

Cai YF, Zhang H, Zeng Y, Mo JC, Bao JK, Miao C, Bai J, Yan F, Chen F. An optimized gossypol high-performance liquid chromatography assay and its application in evaluation of different gland genotypes of cotton.Journal of Biosciences. 2004. 29(1):67-71.

Biological Activity Analysis ofPolygonatum cyrtonemaHua. Lectin by Site-Directed Mutagenesis,Trends in Glycoscience and Glycotechnology疯狂飞艇, 2004,16:pp.s1–s32

In Vitro Plantlet Regeneration from Rhizome Lumps and Mannose-Binding Lectin Analysis ofPolygonatum cyrtonemaHua.(Family Liliaceae) ,Trends in Glycoscience and Glycotechnology(TIGG), 2004,16: pp.S 33–S 64(IF 0.863)

Miao C, Gou XP, Lan LQ, Bao JK, Xu Y, Wang SH, Chen F. Molecular cloning and expression of RSSSG58 gene in rice sperm cells.Acta Botanica Sinica.2003. 45(2):234-241.

Xiang QX, Zhou H, Wang XY, Yu XQ, Bao JK, Xie RG. Interaction between Bifunctional Kioxo Macrocyclic Polyamine Co(II) Complex and DNA in Metallomicellar System.Chinese Chemical Letters.2002. 13(3):223-226.

Bao JK, Zeng ZK. Purification and biological activity of a lectin fromPolygonatum cyrtonemaHua.Eur J Cell Biol 1疯狂飞艇997, 74(Suppl.46): 8.

Bao JK, Zhou H, Zeng ZK. Conformation and activity ofMillettia dielsianna Harms lectin,Eur J Cell Biol,1997,74(Suppl.46):8

国家发明专利:

1、yizhongdalianghuodehuangjingningjisuiidefangfa。zhuanlihao: zl 2004 1 0021659.1

2、huangjingningjisuⅱdanbaizaizhibeizhiliaohuoyufangyixingganyandeyaozhongdeyingyong。zhuanlihao: zl 2004 1 0022354.2

疯狂飞艇3、huangjingningjisuiidanbaizaizhibeizhiliaohuoyufangdanchunpaozhenbingdusuozhijibingdeyaozhongdeyingyong。zhuanlihao: zl 2004 1 0022353.8

疯狂飞艇4、huangjingningjisuiidanbaizaizhibeizhiliaohuoyufangaizibingdeyaozhongdeyingyong。zhuanlihao: zl 2006 1 0005577.7

疯狂飞艇5、yangerlanningjisudanbai、jiyinjiqiyingyong。zhuanlihao: zl 2011 1 0023616.7

疯狂飞艇6、kanghivyaowuanruineiweizaizhibeikangzhongliuyaowuzhongdeyingyong,zl 2013 10532562.6

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