疯狂飞艇

师资队伍

teaching staff

正高

韩源平

发布时间 : 2015年03月24日 浏览量 : 1280

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1.个人简介

email: .cn or

sichuandaxue,shengmingkexuexueyuan

hanyuanping (yuan-ping han,ph.d.) boshi,zaimeiguoxuexigongzuoershiduonianhou,zuoweihaiwairencaiyinjinrencaihuidaomuxiaosichuandaxue,xianrenshengmingkexuexueyuanjiaoshou,meiguocedars-sinai medical centerkezuojiaoshou。yanjiulingyuzhuyaozaiganyinghua,zhifanggan,daixiezonghezhengfashengdezhengheshengli/binglixue。zuoweimeiguonanjiazhoudaxue(university of southern california, usc,keck school of medicine) boshidaoshi, tadeyanjiudedaonational institutes of health(nih)duogejijindezhichi, baokuoliangge5nianr01jijin, gong$2.7 millionyijiqitajijin。zaisichuandaxuede4nianqijian,zaisichuandaxue/985qidongjijindezhichixia,tahuodeleguojiaziranjijin,sichuanshengkejitingkejizhicheng,yijizhiyaogongsikaidekaifajijin。tashimeiguonih, nsf, ouzhouwellcome foundationdejijinpingwei。weiduogezhuanyeqikan, ruhepatology, am j pathology, j biological chemistry, j of immunologyshengao。zaiganzangfangmian, zhuyaocongshiganxingzhuangxibaojiganyinghua,yijizhifanggan(nash)dejiliyanjiu。tachengjingzaizhiyaolingyu(gsk,gelansushikeyanfazongbu,yijisichuankangshengsuyanjiusuo)congshixinyaowudekaifayanjiu。zaimeiguoqijianzhangqiweizhiyaogongsidanrenguwen(consultant)。yanjiufangfashejifenzishengwuxue,shengwuhuaxue,zuzhijixibaoshengwuxue,mianyixue,rentishengli,binglixuedezhenghe,yijizhuanhuajilinchuangyingyong。chulejichuyanjiu,fengkuangfeitingyekaizhanzhenduizhifanggan(nash)/daixiezonghezheng,yijikangganyinghuaxinyaodeyanfa。

huidaochuanda3nianlaijianlileshiyanshiyijidongwufang,you10weiyanjiusheng,fengkuangfeitinghuodeleguojiaziranjijin,sichuanshengkejitingdezhichengjijin,zhongguoganbingfangzhixuehuideyanjiujijin,yijizhiyaochangdekaifajijin。zaijiaoxuefangmian,zhuchiquanyingyushengwuhuaxuekecheng。tongshi,fengkuangfeitingyumeiguocedars-sinai medical center yijinanjiazhoudaxue(usc)kaizhanhezuo,duiyanjiushengcaiyongshuangdaoshizhidu。

2.教育经历

疯狂飞艇•1978-1982, sichuandaxue, shengwuxi, zhuxiushengwuhuaxue, xueshixuewei

•1990-1996, xinaishanyixueyuan (the mount sinai school of medicine, new york), zhuxiushengwuyixuekexue(biomedical science), huoboshixuewei ,ph.d. daoshi, dr. ronald a. kohanski

•1996-1999, nanjiadaluoshanjiertongyiyuanlos angeles children’s hospital/university of southern california, boshihou (1996-1999), daoshi, dr. yun-kai (teddy) fong

3.研究工作经历

疯狂飞艇•1982-1985, dizhikuangchanbugongyiyanjiusuo, zhuliyanjiuyuan

•1985-1989, sichuankangjunsuyanjiusuo, zhuliyanjiuyuan

•1989-1990, smithkline pharmaceuticals (gelansushike, meiguo, feicheng), congshixinyaofaxianyanjiu

•2000-2003, nanjiazhoudaxue university of southern california, keck school of medicine, zhuliyanjiuyuan

•2004-2011, nanjiazhoudaxue university of southern california, keck school of medicine, zhulijiaoshou (assistant professor at tenure track)。 usc keck school of medicine, pibbs boshiyanjiushengdaoshi。

•2004nian-xianzai,nanjiazhoudaxue,keck school of medicine, jiujingganbingjiyixianjibingyanjiuzhongxinhuiyuan

疯狂飞艇•2011-zhijinshoudouyikedaxue,beijingyouanyiyuankezuojiaoshou

•2012-zhijin,cedars-sinai medical center (los angeles), kezuojiaoshou,xiangmuhezuo。

疯狂飞艇•2012-zhijin, sichuandaxue,shengmingkexuexueyuan,jiaoshou。

4.期刊评审

疯狂飞艇journal of clinical investigation

hepatology

疯狂飞艇american journal of pathology

疯狂飞艇american journal of physiology (gastrointestinal and liver physiology)

疯狂飞艇wound repair and regeneration journal

journal of biological chemistry

疯狂飞艇life science journal

journal of the national cancer institute

journal of cellular and molecular medicine

5. 基金评审

national science foundation (nsf)

疯狂飞艇wellcome foundation

national institutes of health (nih)

zhongguoziranjijin

6.研究基金

1. principal investigator: “act, a pathophysiological inhibitor of mmp-9 activation”.

r01, ar051558, niams, 7/1/2004-6/30/2009

the goal of this grant is to identify and characterize alpha-act as a novel inhibitor controlling prommp9 conversion in human skin.

疯狂飞艇2. principal investigator: “hepatic stellate cell derived mmp9 in liver fibrogenesis”.

r01, dk069418, niddk, 9/1/2004-8/30/2009

疯狂飞艇the major goal of this grant is to elucidate the mechanism of fibrogenic activation of hepatic stellate cells, an essential process in liver fibrogenesis. specifically, we have addressed the role of il-1 in ecm remodeling and activation of hepatic stellate cells.

疯狂飞艇3. pilot project investigator: “cytokine regulation of mmps and timps by alcoholic liver”. 5p50aa011999, pilot project grant, niaaa, 12/30/2002-12/31/2004, the aims of this pilot project are to explore the roles of mmps in hepatic stellate cell activation (trans-differentiation) and the inflammation mediated regulation of mmps.

疯狂飞艇4. principal investigator: “purification of the hepatic stellate cell produced prommp-9 activator”

robert e. and may r. wright foundation (ii), 6/30/2004-6/30/2006 we recently demonstrated that il-1a induced mmp-9 has an essential role in trans-differentiation of hepatic stellate cells. however, an outstanding question is that how prommp-9 is converted into active form by hepatic stellate cells. this grant will support us to identify this activator through protein biochemical and genomic approaches. 5. principal investigator: “identification of the cellular factors

疯狂飞艇controlling mmp-9 activation in human skin and implication in cancer metastasis”. robert e. and may r. wright foundation (i), 7/1/2002-6/30/2004

the aim of this project is to purify the putative prommp-9 activator from human skin. through the original work we have 1) defined the cytokine regulation of prommp-9 activation by human skin, 2) established a protocol to extract the activator and 3) characterized the putative activator as a tissue bound chymotrypsin-like proteinase.

6. principal investigator: “the cellular factors promote mmp-9 activation in chronic wound". the plastic surgery education foundation, pi, 2000-2001 the aim of this grant is to understand the cytokine mediated induction of prommp-9 expression by dermal fibroblasts and keratinocytes. the signal transduction leading expression mmp is the key emphasis.

7. principal investigator “regulatory t cells in liver injury and fibrosis”.

疯狂飞艇pilot grant, niddk, issued by the research center of liver diseases. 3/15/2010-6/13/2011

疯狂飞艇8. sichuandaxue,haiwairencaiyinjinjihuaji985jihua,

qidongjijin: ¥ 800,000

疯狂飞艇2012/9/1 – 2016/9/1

9. zhongguoganyanfangzhijijinhuiwangbaoenganxianweihuayanjiujijin

“diaojiexingt-xibaozaizhongduganxianweihuajiganyinghuazhongdeguanjianzuoyong”。

疯狂飞艇¥ 50,000,2014/5/1 - 2015/5/1.

疯狂飞艇10. sichuanshengkejizhichengjihuaxiangmu

“zhifangxingganyanfashengdexitongshengwuxuejikangzhifanggandexinliaofa”188

¥ 200,000;2014/11/13 - 2016/11/13

疯狂飞艇11. chengdoutongdezhiyaogongsi

“duitongdezhiyaogongsixianyouyaowudeercikaifa”

¥ 650,000;2014/11/20 - 2016/11/20

12. zhongguoziranjijin

“weishengsuddiaojiechangdaokangjuntaijijunqun,yidiyudaixiezonghezheng”。#31571165¥ 748,000: 2016/01 - 2019/12.

7、研究领域及成果。

(1) daixiezonghezheng,zhifanggandejilijixinliaofadekaifa。

疯狂飞艇jinnianlaifengkuangfeitingjianggongzuodezhongdiandeyibufenzhuanyidaodaixiezonghezheng,zhifanggan,feipangdejiliyanjiujixinyaowudekaifa。suizheshehuijingjidejudafazhan,daixiezonghezheng(metabolic syndrome,ms) biaoxianweigaoxuezhi,zhifanggan,feipang,tangniaobing,chengmanyanzhishi。jinlaiguanfangdetongji,zhongguoyou1yiliuqianwanrenqunhuanyoubutongchengdudedaixiezonghezheng。zaixifang,sifenzhiyidechengrenweifeipang。daixiezonghezhengdeweixianxingzaiyuyinfatangniaobing,xinxueguanjibing,jinaozhongfeng,yichengweizuizhuyaodesiwangshashou。daixiezonghezhengdefashengyugaotang,gaozhifangyinshiyoumiqieguanxi。gaishanyinshijishenghuofangshishizhiliaodaixiezonghezhengdeyouxiaofangfa。zaiyaowuzhiliaofangfa,jiangdanguchun,jianggaoxueya,jiangxuetangshizhuyaodecelve。lingwai,shiyiweidezhifang(funei)huiguidaozhifangpixiaxibao,yeshifangzhidaixiezonghezhengdexinfangxiang。jiyuduonianlaifengkuangfeitingzaimanxingjibingyanjiudejingyan,fengkuangfeitingcaiyongxitongshengwuxuedefangfa,congxindejiaodujifangfalaiyanjiudaixiezonghezheng。daixiezonghezhengdefashengfenweisangejieduan。diyibu,gaozhifang,gaoguotangyinshiyinqidechangdaojunqun(microbiota)degaibian,zaochengxueyeneidusudeshangshengjifubuzhifangzuzhidemanxingyanzheng。dierbu,manxingyanzhengzaochengyidaosudikang,tangnaishou,iixingtangniaobing。zuoweimibujizhi,gaoxuetangzaiganzangzhuanhuaweizhifangsuan,xingchenggaoxuezhi,zhifanggan。erzhifangganjifuneizhifangchanshengdeyanzhenghuizaochengganzangsunshang,daozhigaomiduzhidanbai(hdl)xiajiang,ningxuejizhizengqiang。disanbu,chixudetangniaobing,gaoxuezhi,ningxueyichang,jiangchanshengxinxueguanzusai,zhongfeng,jiasusiwang。weici,fengkuangfeitingyixitongshengwuxuedefangfa,faxiangaozhifangyinshijiweishengsudquefayoudaochangdaojunqundegaibian,panethxibaokangjunduotaidexiajiang,changdaojifuneizhifang,yixiandediduyanzheng,zaochengyidaosudikang,chanshengzhifanggan,tangnaishou。yicimoxing, fengkuangfeitingjiangchanshudaixiezonghezhengdefashengjili。tongshi,fengkuangfeitingzhengzaiyanjiukaifaquanxindeyaowu,yongyudaixiezonghezhengdeyufangjizhiliao。

疯狂飞艇(2)zuzhixianweihuadexibaoshengwuxue。

zaimeiguonanjiada(university of southern california)gongzuoqijian,zuoweipibingzailianggenih r01jijindezizhuxia,fengkuangfeitingzhangqicongshizheifangmiandeyanjiu。guangyidezuzhisunshangbaokuobingduganran,wuranduwudesheru,jiduozhongmanxingjibing,zhongliudengdeng。sunshangyihou,jitiyouliangzhongxuanze,shizaisheng,haishixiufu。daduoshudezuzhijinyoujixiaodezaishengnengli(liruganzang,pifu)。ercaiyongxiufushidaguimohuoshichixusunshangdeshouyaoxuanze。xiufudezhuyaotezhengshichanshengxianweihuadezuzhijiegou。zuoweijinhuadexuanzejieguo,zuzhixianweihuaduiyujitishiyouyide,taweishiqudezuzhidashangle“buding”,fouzeyinshiqudezuzhi,getibunengxingcun。danshi,chixudexianweihuajiangshidemanxingjibing,liruzhongliudeyichixu。qiguandelaonianshuaijieyeshizuzhixianweihuadejieguo。juguji,dayue50%desiwangdouyuzuzhixianweihuayouguan。daduoshudezhongliuzhisuoyinenggouchixudeyuanyin,zaihendachengdushangshiyinweixianweihuazuzhiweizhongliutigongleshengzhangdehuanjing。fengkuangfeitingdegongzuozhuyaojizhongyuganxingzhuangxibao (hepatic stellate cells) dezhuanfenhua(trans-differentiation)。fengkuangfeitingfaxianzaiganxingzhuangxibaozhuanfenhuaguochengzhong,duogemmpjiyinbeibukenidiguanbi,xiaojing(silencing)。fengkuangfeitingrenwei,zaizhengchangganxuedouzhongxingzhuangxibaodebiaoxingshiyouqi3weiecmtongguobiaoguanyichuan(epigenetic control) suojuedingde。gengjinyibu,genjufengkuangfeitingdefaxian,fengkuangfeitingrenwei3d ecmtongguoxiadiaoii-xinghdac,shimmpjiyinqun(mmp loci) chuyubiaoguanyichuanshuipingdekaifangzhuangtai,zaiyanzhengyinziyinfadexinhaochuandaoxia,nenggoudaliangbiaoda,shifangshengzhangyinzi,kaiqisunshangjixiufu。xingzhuangxibaozaishengzhangyinzidecudongxiazhuanhuaweijichengxianweimuxibao(myofibroblasts), bingxingchengxianweizuzhi。mmpjiyinzaijichengxianweimuxibaodexiaojing,jiangcujinecmdejileiyijixianweihua。fengkuangfeitingfaxian,zaixingzhuangxibaozhuanfenhuaguochengzhong,ii-xinghdacquyushangsheng,danbaizhiwending,daozhimmpjiyinbeiyizhi。fengkuangfeitingjiangjixuhuidayixiawenti: (1)mmpjiyinqundebiaoguanyichuanjingguanzaizhuanfenhuaguochengzhongdegaibian,congkaifangdaoyizhi?(2)ii-xinghdacdejiangjiemei,yijizaixianweihuazhongdezuoyong?(3)3d ecmduiii-xinghdacdediaokongyijizaisunshangzhongmmpjiyindebiaoda。

(3)ganxianweihuazhongdemianyinaishou。

ganxianweihuabudanshiyouyuxingzhuangxibaodezhuanfenhuajijixianweimuxibaodexingcheng,tongyangzhongyaodeshiganyinghuasuochudemianyilaishoudehongguanhuanjing(macro-environment of immune tolerance),shidexianweizuzhimianyubeiqingchu,taoyimianyijiankong (escaping from immune surveillance)。tongshi,mianyilaishouyeweizhongliushengzhang,zhuanyi,ehuatigonghuanjingtiaojian。zaiqianqigongzuozhong,fengkuangfeitingfaxiantianrandiaojiexingtxibao(naturally occurring tregs, ntres) zaigansunshangzhongdexiajiangshiyouyuqixibaodiaowangsuozhi,erzaiganxiufuguochengzhongchanshengdeyoudaoxingtregs(induced tregs, itregs)shiyouyummpjihuodetgf-betacongeryoudaofoxp3suozhi。gaigongzuojinlaibeijournal of molecular cell biology (yingxiangyinzi: 7.3) jieshou。fengkuangfeitingfaxianbansuiganxianweihuadexingcheng,tregsjujiyuxianweiqiaofujin,shuomingtregschanshengdemianyilaishoukenengcujinxianweihuadechixu。dangfengkuangfeitingyongdankangganyutregsshi,faxiannenggoucujinxiaoshuganyinghuadexiaorong,biaomingtregskenengyizhixianweidexiaorong。fengkuangfeitingfaxiantregstongguoshangdiaotimplaiyizhimmp。tongshi,fengkuangfeitingzaiganyinghuabingrendeganzuzhizhongjianchutregsdeshenggao,shuomingkenengdeyinguoguanxi。weici,fengkuangfeitingtichuxindejiashe: ganxingzhuangxibaosuoshifangdemmptongguojihuotgf-beta,bingqiezaiil-1zuoyongxiashifangweijiasuan(retinoic acid)laiyoudaotregs,shixianweihuamianyubeiqingchu。lingyifangmian,yubeijingyouanyiyuanhezuo,fengkuangfeitingyeduiii-xingjushixibao(alternatively activated macrophages) zaixianweihuademianyinaishoukaizhanledalianggongzuo。

8. 发表的文章。

疯狂飞艇peer-reviewed

疯狂飞艇1. yuan-ping han, kohanski ra.

疯狂飞艇“phenylarsine oxide inhibits insulin activation of phosphatidylinositol 3'-kinase”.

疯狂飞艇biochem biophys res commun 1997 oct 9;239 (1):316-21.

疯狂飞艇2. frankel m, bishop sm, ablooglu aj, yuan-ping han, kohanski ra. “conformational changes in the activation loop of the insulin receptor's kinase domain”.

疯狂飞艇protein science 1999 oct; 8(10): 2158-65.

疯狂飞艇3. yuan-ping han, tuan tl, wu h, hughes m, garner wl.

“tnf-alpha stimulates activation of pro-mmp2 in human skin through nf-kappa b mediated induction of mt1-mmp”.

疯狂飞艇journal of cell science 2001; 114(pt 1):131-139.

疯狂飞艇4. yuan-ping han, tai-lan tuan, huayang wu, michael hughes, warren l. garner. “tgf-beta and tnf-alpha mediated induction and proteolytic activation of mmp-9 in human skin”.

journal of biological chemistry. 2001, vol.276 (25); 22341-22350.

5. yuan-ping han, micheal w. hughes, yih-dar nien and warren l. garner.

疯狂飞艇“il-8-stimulated expression of urokinase-type plasminogen activator in human skin and human epidermal cells”.

journal of surgery research. 2002 aug;106(2):328.

疯狂飞艇6. mei chen, fritz k. costa, christopher r. lindvay, yuan-ping han, and david t. woodley.

疯狂飞艇“the recombinant expression of full-length type vii collagen and

characterization of molecular mechanisms underlying dystrophic epidermolysis

bullosa”.

疯狂飞艇journal of biological chemistry. 2002, vol. 277: 2118-2124.

疯狂飞艇7. yuan-ping han, yih-dar nien and warren l.garner.

疯狂飞艇“recombinant human platelet-derived growth factor and transforming growth factor-beta mediated contraction of human dermal fibroblast populated lattices is inhibited by rho/gtpase inhibitor but not require phosphatidylinositol-3’ kinase”.

疯狂飞艇wound repair and regeneration. 2002, vol. 10, 169-176.

疯狂飞艇8. yuan-ping han*, yih-dar nien and warren l.garner.

“tnf-alpha mediated proteolytic activation of pro-mmp-9 in human skin is controlled by down regulation of the tissue inhibitor, timp-1 and mediated by tissue bound chymotrypsin-like proteinase”.

疯狂飞艇journal of biological chemistry. 2002, 277: 27319-27327.

9. yuan-ping han, yih-dar nien and warren l.garner.

“fibrinogen inhibits fibroblast-mediated contraction of collagen”.

wound repair and regeneration. 2003 sep;11(5):380-385.

10. yuan-ping han*, ling zhou, jiaohong wang, shigang xiong, warren l. garner, samuel w. french, hidekazu tsukamoto.

疯狂飞艇“essential role of matrix metalloproteinases in interleukin-1 induced myofibrobalstic activation of hepatic stellate cell in collagen”.

journal of biological chemistry. 2004, vol. 279, 4820-4828

疯狂飞艇11. yuan-ping han, downey s and warren l.garner.

“interleukin-1alpha-induced proteolytic activation of metalloproteinase-9 by human skin”.

surgery. 2005 nov;138(5):932-9.

12. yuan-ping han*.

“matrix metalloproteinases, the pros and cons, in liver fibrosis”.

journal of gastroenterology & hepatology. 2006 oct; 21 suppl 3:s88-91.

疯狂飞艇13. yuan-ping han*, chunli yan, ling zhou, lan qin, and hidekazu tsukamoto.

疯狂飞艇“a matrix metalloproteinase-9 activation cascade by hepatic stellate cells in trans-differentiation in the hree-dimensional extracellular matrix”.

journal of biological chemistry. 2007 apr 27;282(17):12928-39

14. goldberg mt, han yp, yan c, shaw mc, garner wl.

“tnf-alpha suppresses alpha-smooth muscle actin expression in human dermal fibroblasts: an implication for abnormal wound healing”.

journal of investigative dermatology. 2007 may 31;127 (11):2645-55

疯狂飞艇15.cheng jh, she h, han yp, wang j, xiong s, asahina k, tsukamoto h.

“wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis”.

american journal of physiololy, (gastrointest liver physiol) 2007, nov 15; [epub ahead of print] pmid: 18006602

疯狂飞艇16. yuan-ping han*, chunli yan and warren l garner.

疯狂飞艇“proteolytic activation of matrix metalloproteinase-9 in skin wound healing is inhibited by alpha-1-antichymotrypsin”.

疯狂飞艇journal of investigative dermatology. 2008 september; 128(9): 2334–2342.

17. chunli yan, ling zhou, and yuan-ping han*.

“contribution of hepatic stellate cells and matrix metalloproteinase-9 in acute liver failure”.

liver international. 2008 may 26. [epub ahead of print].

18. cheng cf, fan j, fedesco m, guan s, li y, bandyopadhyay b, birght am, yerushalmi d, liang m, chen, han yp, woodley dt, li w.

“transforming growth factor alpha (tgfalpha)-stimulated secretion of hsp90alpha: using the receptor lrp-1/cd91 to promote human skin cell migration against a tgfbeta-rich environment during wound healing”.

molecular cell biolology. 2008 may;28(10):3344-58. epub 2008 mar 10, mid:18332123.

19. ling zhou, chunli yan, wei li, yujiro kida, warren l. garner and yuan-ping han*.

“p21 activated kinase (pak) controls expression of mmp-9”.

bmc immunology 2009, 10:15,19 march

20. roben l. gieling, wallace, k. and yuan-ping han*

“participation of interleukin-1 in liver injury induced fibrosis”.

american journal of physiology, (gastrointest liver physiol) . 2009, vol. 296,1324-31

21. mj reiss, yuan-ping han, e garcia, yk hong, and wl garner.

“ 1-antichymotrypsin activity correlates with and may modulate matrix metalloproteinase-9 in human acute wounds ”.

疯狂飞艇wound healing and regeneration, 2009, published online: may 20 2009, p 418-426

疯狂飞艇22. shengwen calvin li, yuan-ping han, brent a. dethlefs and william gunter loudon.

“therapeutic window of stem cell potential for targeting pediatric malignant brain tumor: an opportunity for stem cell therapy”.

stem cell review and reports, 2009, vol.5, issue 4, p446

23. mj reiss, yuan-ping han, e garcia, yk hong, and wl garner.

“excessive amount of matrix metalloproteinase-9 delays wound healing in a murine wound model”.

surgery, 2010, february, volume 147, issue 2, pages 295-302

疯狂飞艇24. keigo machida, hidekazu tsukamoto, jian-chang liu, yuan-ping han, sugantha govindarajan, michael lai, shizuo akira, james ou, “c-jun mediates hcv hepatocarcinogenesis through stat3 and nitric oxide-dependent impairment of oxidative dna repair”.

疯狂飞艇hepatology, 2010 aug;52(2):480-92

疯狂飞艇25. chunli yang, wesley grimm, warren garner, and yuan-ping han*,

“tumor necrosis factor-alpha induced epithelial-to-mesencymal transition in human skin fibrogenesis is mediated by bone morphogenetin protein-2”.

american journal of pathology, 2010, may. 176: 2247-2258. (cover story)

26. lan qin and yuan-ping han*.

“epigenetic repression of matrix metalloproteinases in myofibroblastic hepatic stellate cells through histone deacetylases 4,implication in tissue fibrosis ”.

疯狂飞艇american journal of pathology, 2010, volume 177, issue 4, page 1915 (monthly highlight)

27. xiaohui zhou, zanxian xia, qin lan, julie wang, wenru su,yuan-ping han, huimin fan, zhongmin liu, william stohl, and song guo zheng.

“baff promotes th17 cells and aggravates experimental autoimmune encephalomyelitis”.

疯狂飞艇plos one, 2011; 6(8): published online 2011 august. doi: 10.1371, pmcid: pmc3163640

28. yujiro kida, zan xian xia, sujun zheng, nick m. mordwinkin, stan g. louie, song guo zheng, min feng, hongbo shi, zhongping duan, and yuan-ping han*. “interleukin-1 as an injury signal mobilizes retinylesters in hepatic stellate cells through down regulation of lecithin retinol acyltransferase”.

plos one, 2011. 6(11): e26644. doi:10.1371/journal.pone.0026644

29. ling lu, jilin ma, zhiyuan li, qin lan, maogen chen, ya liu, zanxian xia, julie wang, yuan-ping han, wei shi, valerie quesniaux, bernhard ryffel, david brand, bin li, zhongmin liu, song guo zheng.

“all-trans retinoic acid promotes tgf-β-induced tregs via histone modification but not dna demethylation on foxp3 gene locus”.

plos one, 2011; 6(9): e24590. doi:10.1371/journal.pone.0024590.

疯狂飞艇30. liyan chen, feng ren, haiyan zhang, tao wen, zhengfu piao, li zhou, sujun zheng, jing zhang, yu chen, yuanping han, zhongping duan, yingji ma.

“inhibition of glycogen synthase kinase 3b ameliorates d-galn/lps-induced liver injury by reducing endoplasmic reticulum stress-triggered apoptosis”

plos one, 2011. september 2012 | volume 7 | issue 9 | e45202

31. yuan-ping han*, ming kong, sujun zheng, yang ren, hongbo shi, and zhongping duan.

“vitamin d in liver diseases: from mechanisms to clinical trials”.

疯狂飞艇journal of gastroenterology and hepatology. 2013; 28, suppl.1: 49–55

疯狂飞艇32. ling lu, min feng, lan qin et al., yuan-ping han*.

“restoration of intrahepatic regulatory t cells through mmp-9/13-dependent activation of tgf-β is critical for immune homeostasis following acute liver injury”.

疯狂飞艇journal of molecular cell biology. (2013) 5 (6): 369-379

33. wei l, ren f, zhang x, wen t, shi h, zheng s, zhang j, chen y, han y, duan z.

疯狂飞艇“oxidative stress promotes d-galn/lps-induced acute hepatotoxicity by increasing glycogen synthase kinase 3β activity”.

inflammation research. 2014 jun; 63(6):485-94. doi: 10.1007/s00011-014-0720-x. epub 2014 feb 16.

34. kong m, zhu l, bai l, zhang x, chen y, liu s, zheng s, pandol sj, han yp, duan z.

疯狂飞艇“vitamin d deficiency promotes nonalcoholic steatohepatitis through impaired enterohepatic circulation in animal model”.

疯狂飞艇american journal of physiology, gastrointest liver physiol. 2014 nov 1;307(9):g883-93. doi: 10.1152/ajpgi.00427.2013. epub 2014 sep 11.

pmid: 25214402 [pubmed - in process]

35. liu l, ye th, han yp, song h, zhang yk, xia y, wang ny, xiong y, song xj, zhu yx, li de l, zeng j, ran k, peng ct, wei yq, yu lt.

疯狂飞艇“reductions in myeloid derived suppressor cells and lung metastases using azd4547 treatment of a metastatic murine breast tumor model”.

cell physiol biochem. 2014;33(3):633-45. doi: 10.1159/000358640. epub 2014 mar 4. pmid: 24642893 [pubmed - in process]

36. zheng sj, liu s, liu m, mccrae ma, li jf, han yp, xu ch, ren f, chen y, duan zp.

“prognostic value of m30/m65 for outcome of hepatitis b virus-related acute-on-chronic liver failure”.

疯狂飞艇world j gastroenterol. 2014 mar 7;20(9):2403-11. doi: 10.3748/wjg.v20.i9.2403.

疯狂飞艇pmid: 24605039 [pubmed - in process

37. zhang x, feng m, liu x, bai l, kong m, chen y, zheng s, liu s, wan yy, duan z, han yp.

“persistence of cirrhosis is maintained by intrahepatic regulatory t cells that inhibit fibrosis resolution by regulating the balance of tissue inhibitors of metalloproteinases and matrix metalloproteinases”.

translational research. 2015 nov 6. pii: s1931-5244(15)00389-8. doi: 10.1016/j.trsl.2015.10.008. [epub ahead of print]

疯狂飞艇pmid: 26613891

疯狂飞艇38. zhu l, kong m, han yp, bai l, zhang x, chen y, zheng s, yuan h, duan z.

“spontaneous liver fibrosis induced by long term dietary vitamin d deficiency in adult mice is related to chronic inflammation and enhanced apoptosis”.

疯狂飞艇can j physiol pharmacol. 2015 may;93(5):385-94. doi: 10.1139/cjpp-2014-0275. epub 2015 mar 3.

pmid: 25894394

疯狂飞艇39. li zhou, xiaoyu liu, feng ren, yu chen, sujun zheng, yuanping han, caiyan zhao, zhongping duan

“changes in mitochondrial toxicity in peripheral blood mononuclear cells during four-year administration of entecavir monotherapy in chinese patients with chronic hepatitis b”

疯狂飞艇med sci monit. 2015; 21: 2058–2063. published online 2015 july 15. doi: 10.12659/msm.892937. pmcid: pmc4515935

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