疯狂飞艇

师资队伍

teaching staff

正高

肖智雄

发布时间 : 2012年02月10日 浏览量 : 2114

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肖智雄 教授 博导

职务:


●sichuandaxueshengmingkexuexueyuanxueshuyuanzhang

●zhongguoqiaoliantepinzhuanjia

疯狂飞艇●sichuanshengdiyipi“bairenjihua”ruxuanzhe

●sichuanshenghuarenhuaqiaozhuanyerenshilianyihuifuhuizhang

●sichuandaxueshengzhangdaixieshuailaoyanjiuzhongxinzhuren

疯狂飞艇●sichuandaxuexiaoxueshuweiyuanhuiweiyuan

●sichuandaxuezhuanyejishuzhiwupingpinweiyuanhuiweiyuan

●meiguoboshidundaxueyixueyuanzhengjiaoshou, boshizhaoshengweiyuanhuizhuxi,boshizhidaoweiyuanhuizhuxi

●meiguoaizhengyanjiuxiehui(american association of cancer research)huiyuan

●meiguoshenghuahefenzishengwuxuexiehui(american society of biochemistry and molecular biology)huiyuan

●meiguoweishengwuxiehui(american society for microbiology)huiyuan

●meiguokexuecujinhui (american association for advanced sciences)huiyuan

●zhongguoshengwuhuaxueyufenzishengwuxuexuehuilishi

●renmeiguonih,meiguoguofangbu,yidali,faguo, yingguo,xianggangdengjijinhuijijinshenqingpingshenren,wei nature, cell, mcb, oncogene, jcb, cancer research, trends in cell biology dengzazhiteyueshengaoren

疯狂飞艇●chuangjianbingdanrenmeizhongshengwuyixuezhuanjiaxiehui(acpb) yijiboshidunshengwujishuxiehui(bbb) zhuxi(1995-2000), mingyuzhuxi(2000-)。meiguodaboshidundiquchuandaxiaoyouhuizhuxi(2006-2008)。



电话: Email:.cn



简历:

sichuandaxueshengwuxishengwuhuaxuezhuanyehuolixuexueshixuewei(1982nian)helixueshuoshixuewei(1985nian)。

sichuandaxueshengwuxizhujiao(1985)

疯狂飞艇jiaoyubuzhongmeishenghuahefenzishengwuxueliumeixiangmu (cusbmbea)xuanbahuoxuan,liuxuemeiguo(1986)

huomeiguomashengdaxue(university of massachusetts at amherst)fenzishengwuxueboshixuewei(1990)

疯狂飞艇hafodaxueboshihou(1991-1995)

meiguoboshidundaxueyixueyuanshenghuaxiheyixuexizhulijiaoshou(1996),fujiaoshou(2001),zhengjiaoshou (2007)。

disijunyidaxuekezuojiaoshou(1998-2002)

zhongguoxieheyikedaxuekezuojiaoshou(1999-2004)

sichuandaxuekezuojiaoshou (1998-2004)。

疯狂飞艇zhongyangdangxiaopeixunban (2010,4)



研究方向:

疯狂飞艇zhongliufenzishengwuxue,xinhaochuandi, xibaoshengzhangdaixieyushuailao,zhuanhuayixue



研究内容:

kangzhongliujiyin p53 he rb jijiazuchengyuandegongnenghediaokong

dna sunshanghexibaoxiepoduixibaoshengzhang,diaokong,daixieheshuailaodediaokongjixinhaochuandaotonglu

疯狂飞艇danbaizhilinsuanhua,yixianhua,fansuhuajijiajihuaduizhongliufashengzhongyaodanbaidediaokong

jiyinbiaodadiaokong,jisuanjishengwumoxingjiqiyunyong

疯狂飞艇kangaiyaowushaixuanhejianding。zhuanhuayixueyingyongyanjiu。



代表性论文:

1.hiroyuki inuzuka, alan tseng, daming gao, bo zhai, qing zhang, shavali shaik, lixin wan, xiaolu l. ang, caroline mock, haoqiang yin, jayne m. stommel, steven gygi, galit lahav, john asara, zhi-xiong jim xiao, william g. kaelin, jr., j. wade harper and wenyi wei. phosphorylation by casein kinase i promotes the turnover of the mdm2 oncoprotein via the scfb-trcp ubiquitin ligase. cancer cell, in press.

疯狂飞艇2.du, w., wu, j., walsh, em., zhang, y., chen, cy., and xiao zx, nutlin-3a affects expression and function of retinoblastoma protein: a role of retinoblastoma protein in cellular response to nutlin-3a. j. biol. chem. 284: 26315-26321, 2009.

3.qiu, w., wu, j., walsh, w. m., zhang, y., chang, c-y., fujita, j., and xiao zx. retinoblastoma protein modulates gankyri-mdm2 in regulation of p53 stability and chemosensitivity in cancer cells. oncogene 27:4034-4043, 2008.

4.jin y, zeng sx, sun xx, lee h, blattner c, xiao z, lu h. mdmx promotes proteasomal turnover of p21 at g1 and early s phases independently of, but in cooperation with mdm2. mol. cell. biol. 28:1218-1229, 2008.

5.chang, dlf., qiu, w.. ying, h., zhang, y., chen, cy., and xiao zx. arf promotes accumulation of retinoblastoma protein through inhibition of mdm2. oncogene 26: 4627-4634, 2007.

6.ying, h. and xiao, zx. targeting retinoblastoma protein for degradation by proteasomes. cell cycle 5:506-508, 2006.

7.ying, h., chang, dl., zheng, h., mckeon, f., and xiao, z.x. the dna-binding and transactivation activities are essential for tap63 protein degradation. mol. cell. biol. 25:6154-6164, 2005.

疯狂飞艇8.sdek, p., ying, h., chang, dl., qiu, w., zheng, h., allday, mj and xiao, z.x. mdm2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein. mol. cell 20:699-708, 2005.

疯狂飞艇9.sdek, p., ying, h., zheng, h., margulis, a., tang, x., tian, k. and xiao. z.x. the central acidic domain of mdm2 is critical in inhibition of retinoblastoma -mediated suppression of e2f and cell growth. j. biol. chem. 279: 53317-22. 2004

10.murray, s.a., zheng, h., gu, l. and xiao, z.x. igf-1 activates p21 to inhibit uv-induced cell death. oncogene 22: 1703-1711, 2003.

疯狂飞艇11.zheng, h., you, h., zhou, x. z., murray, s.a., uchida, t., wulf, g., gu, l., tang, x., lu, k.p. and xiao, z.x. the prolyl isomerase pin1 is a novel regulator of p53 in genotoxic response. nature 419: 849-853 (with news and views 419:795-797), 2002.

疯狂飞艇12.xiao, z.x., chen, j., levine, a. j., modjtahedi, n., xing, j., sellers, w. r. and livingston, d. m. interaction between the retinoblastoma protein and the oncoprotein mdm2. nature, 375, 694-698, 1995.

13.xiao, z.x. ginsberg, d., ewen, m. and livingston, d. m. regulation of the grossman, s.r., perez, m., joseph, m., mansur, c., xiao, z.x., kumar, s., howley, p.m. and livingston, d.m. p300/mdm2 complexes participate in mdm2-mediated p53 degradation. mol. cell 2: 405-415, 1998.

疯狂飞艇14.xiao, z.x. ginsberg, d., ewen, m. and livingston, d. m. regulation of the retinoblastoma protein-related protein p107 by g1 cyclin-associated kinases. proc. natl. acad. sci. usa. 93, 4633-4637, 1996.



获奖:

疯狂飞艇1991huomeiguoanna fullerjijinhuidebohouyanjiujiang, 1995meiguoaizhengxuehuizishenbohouyanjiuxuezhejiang。2006 nianshourumeiguomingrenlu. huoduoxiangmeiguonihduliyanjiuyuanyanjiuxiangmuzijin, meiguoguofangbuaizhengyanjiuzhuanxiangjijin,meiguoaizhengxiehuixiangmuyanjiujijinyijimeiguomazhouaizhengyanjiuzhuanxiangjijin,boshidundaxueyixueyuanwing tang lee jijinhuiyanjiujijin。shiyanshiyou4mingboshihouhe6mingboshishengfenbiehuomeiguonihboshihou/boshiyanjiujiang, meiguoguofangburuxianaiyanjiuboshiyanjiujijin,boshidundaxuezuijiaboshilunwenqiangbaojiang,yijiboshidundaxueyixueyuanzuijialunwenjiang。

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