疯狂飞艇

师资队伍

teaching staff

正高

朱晓峰

发布时间 : 2016年06月10日 浏览量 : 1347

朱晓峰_副本.jpg

朱晓峰博士,教授,博士生导师

2006年6月获英国斯特拉思克莱德大学和格拉斯哥大学联合授予的生物科学博士学位。博士毕业至2012年9月在英国圣安德鲁斯大学从事研究工作6年,参与了多项由英国生物技术研究委员会(BBSRC)资助的酶学和结构生物学研究重大项目。2012年10月回四川大学生命科学学院工作,主要以天然产物生物合成途径中具有特殊催化功能的酶为研究对象,开展酶晶体结构和催化反应机理的研究,以通讯作者或第一作者发表文章在Nat Commun, JACS, JBC, JMB等学术期刊上。

研究方向

jiegoushengwuxueyanjiuzhuyaotongguox-shexianjingtiyanshe、hecigongzhenhuodianjingdefangfazhiguanfanyingshengwudafenzidejing、dongtaijiegoujiqixianghuzuoyong,zhijiechanmingjibenshengmingxianxiang,yinerchengweixiandaishengmingkexueyanjiudezhongyaozhuliuqianyanfangxiang。benketizuzhuyaoyishengwutangzufen、shengwuluhuawudengteshutianranchanwudeshengwuhechengguochengweiyanjiuduixiang,yunyongx-shexiandanjingyanshefenxiduitangjizhuanyimei、luhuameijinxinglegaofenbianlvdesanweijiegoujiexi,bingjieheqitameixueyanjiufangfa,zhiguanfanyingmeidecuihuaguocheng,touchejieshilezheixiemeidehuaxuefanyingjili,weimeigongnengdegaizaoheyunyong,xinxingyaowudeshejikaifatigonglelilunjichu。

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benketizuhaijiangliyongjiegoushengwuxueyanjiutigongdexinxi,tongguoduimeijiegoudegaizao,yingxiangqimeixuexingzhihecuihuaxiaoneng;kaizhanduogongnengtaifuhewu、duogongnengmeiqianhetiheduogongnengyimiaodehechengshengwuxueyanjiu。

联系方式

学历

疯狂飞艇1995-1999nian benke sichuandaxueshengmingkexuexueyuanshengwujidiban

1999-2002nian shuoshi sichuandaxueshengmingkexuexueyuanshenghuayufenzishengwuxuezhuanye

2002-2006nian boshi yingguositelaisikelaidedaxueuniversity of strathclydegelasigedaxueuniversity of glasgowliangsuodaxuelianheshouyushengmingkexuezhuanyeboshixuewei

工作简历

2006-2012yingguoshengandelusidaxueuniversity of st andrewsshengwuyixuekexuezongheyanjiuzhongxin(bsrc)

2012.10 sichuandaxue

发表文章

疯狂飞艇yang j., wang y., wang t., jiang j., botting c., liu h., chen q., yang j., naismith j.,zhu x.*, chen l.*, pironetin reacts covalently with cysteine-316 of α-tubulin to destabilize microtubule. nat commun, 2016 (accepted and online) (gongtongtongxunlianxiren)

Zhao Y., Yan B., Yang T., Jiang J., Wei H.,Zhu X.*,Purification and crystallographic analysis of a FAD-dependent halogenase from Streptomyces sp. JCM9888.Acta Crystallogr F Struct Biol Commun, 71:972-976, 2015 (通讯联系人)

Zhu G., Ren S., Xi L., Du L.*,Zhu X.*, Temperature induced structural transitions from native to unfolded aggregated states of tobacco etch virus protease.Journal of Molecular Structure疯狂飞艇, 1082: 80-90, 2015 (共同通讯联系人)

Wang Z., Xiang Q.,Zhu X., Dong H., He C., Wang H., Zhang Y., Wang W.,* Dong C.,* Structural and functional studies of conserved nucleotide-binding protein LptB in lipopolysaccharide transport.Biochemical and Biophysical Research Communications, 452(3): 443-449, 2014

Koehnke J, Bent AF, Zollman D, Smith K, Houssen WE,Zhu X., Mann G, Lebl T, Scharff R, Shirran S, Botting CH, Jaspars M, Schwarz-Linek U, Naismith JH., The cyanobactin heterocyclase enzyme: a processive adenylase that operates with a defined order of reaction,Angew Chem Int Ed Engl疯狂飞艇, 52(52):13991-13996, 2013

Lapthorn AJ*,Zhu X., Ellis EM, The diversity of microbial aldo/keto reductases from Escherichia coli K12,Chem Biol Interact, 25; 202(1-3):168-77, 2013

Zhu X.,Yan X., Carter L., Liu H., Graham S., Coote P. and Naismith J.H*, A model for 3-methyladenine recognition by 3-methyladenine DNA glycosylase I (TAG) from Staphylococcus aureus,Acta Crystallogr Sect F Struct Biol Cryst Commun疯狂飞艇, 68 (6): 610-615, 2012

Zhu X., van Pée K.-H. and Naismith J.H*, The ternary complex of PrnB (the second enzyme in pyrrolnitrin biosynthesis pathway), tryptophan and cyanide yields new mechanistic insights into the indolamine dioxygenase superfamily,J Biol Chem疯狂飞艇, 285: 21126-21133, 2010

Zhu X., Laurentis W.D., Leang K., Hermann J., Ihlefeld K., van Pée K.-H. and Naismith J.H.*, Structural insights in the regioselectivity in the enzymatic chlorination of tryptophan,J Mol Biol, 391: 74-85, 2009

Flecks S., Patallo E.P.,Zhu X., Ernyei A.J.,Seifert G., Schneider A. Dong C. Naismith J.H. and van Pée K.-H.*, New Insights into the Mechanism of Enzymatic Chlorination of Tryptophan,Angew Chem Int Ed疯狂飞艇, 47:9533 -9536, 2008

Deng H., Huang F., Naismith J.H., O'Hagan D., Spencer J.B. andZhu X., Biological Fluorination in Streptomyces cattleya:The Fluorinase, in Fluorine and Health: Molecular Imaging, Biomedical Materials and Pharmaceuticals, Chapter 18, 761-777, 2008

Zhu X., Robinson D.A., McEwan A.R., O’Hagan D. and Naismith J.H.*, Mechanism of EnzymaticFluorination in Streptomyces cattleya,J Am Chem Soc, 129: 14597-14604, 2007

Zhu X., Lapthorn A.* and Ellis E., The crystal structure of mouse succinic semialdehyde reductase AKR7A5: The structural basis for substrate specificity,Biochemistry疯狂飞艇, 45: 1562-1570, 2006

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