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四川大学田卫东/李中瀚/陈国庆发现并鉴定一种新型CD24a+牙髓再生多能干细胞-MDPSCs

发布时间 : 2020年04月10日 浏览量 : 1221

牙齿是承担人类咀嚼、发音以及维持颜面美观的重要器官,亦是研究外胚层起源组织器官发育的经典模型之一。作为维持牙齿活力和正常生理功能的关键组织,牙髓富含毛细血管网、末梢神经网络以及成牙本质细胞和各类滋养细胞[1-3],因其与牙本质紧密相连且皆发育自牙乳头组织,因此亦被称为牙髓-牙本质复合体。细菌感染、物理损伤以及化学和免疫因素等均可造成牙髓炎症和坏死的发生,而目前的根管治疗仅着眼于炎症抑制和脓坏组织去除,治疗后的牙齿失去活性牙髓滋养,最终易发生断裂、缺失。因此,牙髓-牙本质复合体的再生一直是口腔再生医学研究的重要方向。随着组织工程技术的发展,利用干细胞再生功能性牙髓的组织再生技术正逐渐成为研究者探索牙髓炎症和坏死治疗的新趋势。尽管当前自牙齿组织中分离出的多种间充质干细胞均被尝试用于牙髓-牙本质复合体再生,但牙髓干细胞特征性标志物的缺乏、间充质干细胞本身的异质性[4-6]以及传统二维培养方式在长期维持干细胞多能性上的局限性[7],显著阻碍了其在牙髓-牙本质复合体再生中的应用。

2020nian4yue8ri,sichuandaxuetianweidongjiaoshou、lizhonghanjiaoshouhechenguoqingfujiaoshoudeyanjiuxiaozuzaiscience advancesfabiaotiwei“regeneration of pulpo-dentinal–like complex by a group of unique multipotent cd24a+ stem cells” deyanjiulunwen。gaiyanjiuliyongjianchongzhixibaozhichixingde3dpeiyangtixi,congxiaoshuyarutouzhongfaxianleyiqunzaisanweipeiyanghuanjingzhongnengxingchengganxibaoxiaoqiudexibaoyaqun。gaixibaobiaodaduozhongganxibaobiaozhiwujiyin,ruoct4, nanog, sox2dengbingnengzaitiwaizhangqibaochizigengxinyuduonengxing;dangganxibaoxiaoqiuyutdmcailiaofuheyizhiluoshupixiahoukegaoxiaolvxingchengzaishengxingyabenzhi、maoxixueguanwang、moshaoshenjingwangluodeng,qiezaishengzuzhidexibaopailieyuyuanshengyachileisi;jinyibudeyanjiufaxian,gaixibaoqunyicd24aweiqitezhengxingbiaozhiwu,qiegaibiaozhiwudefujiyuxi

胞的多能性呈现正相关性;研究人员还发现,该细胞的自更新能力,高度依赖于转录因子Sp7的表达。最后,该类细胞被命名为:  MDPSCs (Multipotent Dental Pulp regenerative Stem Cells)。MDPSCs可作为牙齿干细胞组织工程再生技术的新型种子细胞,为牙髓-牙本质复合体的高效率再生带来新突破。

gailunwenyousichuandaxuehuaxikouqiangyixueyuan/shengmingkexuexueyuanlianhepeiyangxueshengchenhongboshiweidiyizuozhe,shengmingkexuexueyuanlizhonghanjiaoshou、huaxikouqiangyiyuantianweidongjiaoshou、chenguoqingfujiaoshouweigongtongtongxunzuozhe,lizhonghanjiaoshouweigailunwendezhuyaolianxiren(lead contact)。sichuandaxueshengmingkexuexueyuanxueshengfuhuancheng、wuxue、huhong、liaoyuansongyijihuaxikouqiangyixueyuanxueshengduanyufeng、zhangsicheng,wangtao,yangyancanyulebenxiangmuyanjiu。gaixiangyanjiuhuodeleguojiazhongdianyanfajihua“ganxibaojizhuanhuayanjiu”zhuanxiang、zhongkeyuanxiandaojihua、guojiaziranjijin、zhongyanggaoxiaojichuyanfajingfeidezizhu。

 

   

 

 

yuanwendoi: 10.1126/sciadv.aay1514

cankaowenxian:

1. y, c., et al., pulp-dentin regeneration: current state and future prospects. journal of dental research, 2015. 94(11): p. 1544-51.

2. gt, h., et al., stem/progenitor cell-mediated de novo regeneration of dental pulp with newly deposited continuous layer of dentin in an in vivo model. tissue engineering. part a, 2010. 16(2): p. 605-15.

3. sr, s., et al., dentin-pulp complex regeneration: from lab to clinic. advances in dental research, 2011. 23(3): p. 340-5.

4. bianco, p., p.g. robey, and p.j. simmons, mesenchymal stem cells: revisiting history, concepts, and assays. cell stem cell, 2008. 2(4): p. 313-9.

5. pevsner-fischer, m., s. levin, and d. zipori, the origins of mesenchymal stromal cell heterogeneity. stem cell rev, 2011. 7(3): p. 560-8.

6. takahashi, a., et al., autocrine regulation of mesenchymal progenitor cell fates orchestrates tooth eruption. proc natl acad sci u s a, 2019. 116(2): p. 575-580.

7. pastrana, e., v. silva-vargas, and f. doetsch, eyes wide open: a critical review of sphere-formation as an assay for stem cells. cell stem cell, 2011. 8(5): p. 486-98.

 

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